Search Results - ResearchProducts+%3e+Antibodies

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Affinity Purified Polyclonal Antibody Against Vangl2 (Van Gogh-like) as a Research Tool Product

This technology includes an antibody that enables the identification and isolation of the protein and protein partners of Vangl2 for application by western blotting, immunoprecipitation and immunocytochemistry. Because planar cell polarity signaling disruption leads to direct or indirect pathologies including malformation of the neural tube, mental...

Published: 8/12/2024 | Inventor(s): Mireille Montcouquiol

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Antibodies

Immunogens, Compositions, and Methods for the Treatment of Dyslipidemia

This technology includes a novel vaccine for forming autoantibodies against apoC-III, a plasma enzyme that inhibits lipolysis. The vaccine can possibly be used to treat patients with high triglycerides and are at risk for pancreatitis and cardiovascular disease. This disclosure describes an ApoC3 immunogen that includes an antigenicApoC3 peptide linked...

Published: 8/12/2024 | Inventor(s): Alan Remaley

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Metabolic Disease

Monoclonal Antibody Against Human Zinc Finger RNA-binding Protein (ZFR)

This technology includes monoclonal antibody was raised in mice against amino acids 703-1074 of ZFR. Antibody specificity was confirmed by immunoblotting lysates from cells depleted of ZFR using shRNAs.

Published: 8/12/2024 | Inventor(s): John Hogg, Nazmul Haque

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Materials Available, ResearchProducts > Antibodies

Antibody to Mitochondrial Uniporter (MCU

This technology includes a generated polyclonal antibody in rabbit that detects the mitochondrial uniporter (MCU) protein. This antibody was created by immunizing rabbits with a synthesized sequence of the MCU protein and can be used to identify and quantify MCU protein in various tissues. The polyclonal nature of the antibody ensures it recognizes...

Published: 8/12/2024 | Inventor(s): Toren Finkel, Xin Pan

Keywords(s):

Category(s): Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies

Human Monoclonal Antibodies to Generate Chimeric Antigen Receptor (CAR) T-cells to Treat Patients with Advanced Clear Cell Renal Cell Carcinoma (ccRCC).

This technology includes six human monoclonal antibodies (mAbs) that target tumor antigens derived from the CT-RCC HERV-E (human endogenous retrovirus type E) to generate Chimeric Antigen Receptor (CAR) T cells to treat patients with advanced clear cell renal cell carcinoma (ccRCC). These mAbs were identified from Adagene Inc’s human antibody...

Published: 8/12/2024 | Inventor(s): Richard Childs, Long Chen, Elena Cherkasova

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, Collaboration Sought > Materials Available, ResearchProducts > Antibodies, TherapeuticArea > Oncology

Monoclonal Anti-mouse and Anti-human TL 1A Antibodies for Diagnostic and Therapeutic Utilization

This technology includes antibodies against TL 1A for the inhibition of TL 1A-DR3 interactions for the diagnosis and treatment of various autoimmune diseases. Through the use of our developed hamster anti-mouse and mouse anti-human monoclonal antibodies, we’ve demonstrated that treatment with anti-mouse TL 1A prevented collagen-induced arthritis...

Published: 7/30/2024 | Inventor(s): Richard Siegel, Francoise Meylan, Yun-Jeong Song

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Immunology

Evans Blue Modified Small Molecule-based Prostate-specific Membrane Antigen (PSMA) Radiotherapy and Nuclear Imaging

This technology includes anti-PSMA antibody labeled with 177Lu, which has shown to be an effective treatment for prostate cancer. Several small molecules targeting PSMA were also evaluated in prostate cancer patients labeled with betta emitters such as 177Lu. The most common one is 177Lu-PSMA-617 which is under clinical evaluation in many countries....

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Oncology

Intranasal or Inhaled Delivery of a Custom IgA Antibody for Protection Against COVID-19

This technology includes an IgA antibody, specifically designed to target the receptor binding domain of SARS-CoV-2, the virus causing COVID-19. Administered intranasally, this antibody has potential neutralizing activity, aiming to prevent COVID-19. IgA, an antibody class present in mucosal areas, plays a crucial role in immune defense at the initial...

Published: 8/12/2024 | Inventor(s): Kaitlyn Sadtler, Mathew Memoli

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Infectious Disease

Antibody Targeting of Cell Surface Deposited Complement Protein C3d as a Treatment for Cancer

This technology includes monoclonal antibodies (mAb) that specifically and with high affinity bind the final complement components C3dg and C3d (subsequently referred to as C3d), which can be used to kill tumor cells that carry C3d on their cell surface. We show that tumor cells of patients treated with the therapeutic anti-CD20 mAb ofatumumab carry...

Published: 8/12/2024 | Inventor(s): Martin Skarzynski, Adrian Wiestner, Margaret Lindorfer, Ronald Taylor, Christoph Rader, Berengere Vire

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Oncology

Cytochrome P450 CYP2J Polyclonal Antibodies and Recombinant Proteins for Immunoblotting and Metabolism Studies

This technology includes identified members of the mouse cytochromes P450 CYP2J subfamily and antibodies to them for P450 expression studies and metabolism research. Recombinant proteins of the CYP2J subfamily members have also been expressed. The CYP2J subfamily members have a wide tissue distribution and may be useful as model systems for studies...

Published: 8/12/2024 | Inventor(s): Joan Graves, Darryl Zeldin, Joyce Goldstein, Jennifer Bradbury, Joyce Blaisdell

Keywords(s):

Category(s): Application > Research Materials, ResearchProducts > Antibodies, ResearchProducts > Plasmids/Vectors, TherapeuticArea > Metabolic Disease

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