Search Results - listed+lpm+reichman+as+of+4%2f15%2f2015

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Capsid-Free AAV Vectors for Gene Delivery and Their Use for Gene Therapy
The invention concerns novel capsid-free AAV vectors that can be used for gene delivery and gene therapy applications. The invention provides for a linear nucleic acid molecule comprising in this order: a first adeno-associated virus (AAV) inverted terminal repeat (ITR), a nucleotide sequence of interest, and a second AAV ITR, wherein said nucleic acid...
Published: 7/25/2024   |   Inventor(s): Lina Li, Luis Garcia, Cyriaque Beley, Thomas Voit, Robert Kotin
Keywords(s): AAV, Cell, Clonal, Containing, DNA, GB2AXX, Lines, Listed LPM Reichman as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Rescueable, Sf9, STABLE, Vector, VPXXXX, WJXXXX, XEXXXX, YAXXXX, YBXXXX
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Dental, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Ophthalmology, TherapeuticArea > Oncology, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease
AAV5 Vector and Uses Thereof
The invention described and claimed in this patent application provides for novel vectors and viral particles which comprise adeno-associated virus serotype 5 (AAV5). AAV5 is a single-stranded DNA virus of either plus or minus polarity which, like other AAV serotypes (e.g., AAV4, AAV2) requires a helper virus for replication. AAV type 2 has the interesting...
Published: 7/25/2024   |   Inventor(s): Robert Kotin, John (Jay) Chiorini
Keywords(s): AAV, AAV5, control seq, Duke DNA Project, GB2A1X, GB2A2X, GB2AXX, GB2XXX, GBXXXX, GENE THERAPY, GXXXXX, Listed LPM Reichman as of 4/15/2015, Patent Category - Biotechnology, PCT/US99/11958; WO 99/61601 (12/02/99), Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, viral vector
Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
AAV5 Vector for Transducing Brain Cells and Lung Cells
The invention described and claimed in this patent application is related to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using an Adeno-Associated Virus of serotype 5 (AAV5)....
Published: 7/25/2024   |   Inventor(s): Beverly Davidson, Robert Kotin, Joseph Zabner, John (Jay) Chiorini
Keywords(s): AAV, AAV5, brain, CB2AXX, CBXXXX, CXXXXX, GB2A2X, GB2XXX, GENE THERAPY, IB4XXX, IBXXXX, IXXXXX, Listed LPM Reichman as of 4/15/2015, LUNG, NB1XXX, NBXXXX, NXXXXX, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, USES, Vector, viral vector
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Pulmonology, TherapeuticArea > Oncology, TherapeuticArea > Neurology, Application > Research Materials, Application > Diagnostics, Application > Therapeutics
AAV4 Vector and Uses Thereof
The invention described and claimed in this patent application relates to the delivery of heterologous nucleic acids or genes to particular target cells. In particular, the application relates to methods of delivering a heterologous nucleic acid or gene of interest to particular target cells using Adeno-Associated Virus of serotype 4 (AAV4). The particular...
Published: 7/25/2024   |   Inventor(s): Robert Kotin, Brian Safer, Beverly Davidson, John (Jay) Chiorini
Keywords(s): AAV, AAV4, brain, CB2AXX, CBXXXX, CXXXXX, ependymal cells, GB2A2X, GB2XXX, GENE THERAPY, Listed LPM Reichman as of 4/15/2015, NB1XXX, NBXXXX, NXXXXX, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, SACGHS DNA Patent Initial Set, USES, viral vector
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics, TherapeuticArea > Neurology
Novel Genetic Tristetraprolin (TTP) Knock-in Mouse
Tristetraprolin (TTP) is the prototype member of a small family of RNA binding proteins that bind to specific types of AU-rich elements in the 3'UTRs of target mRNAs and promote their rapid turnover. One of the targets destabilized by TTP is Tumor necrosis factor alpha (TNF). TNF has long been a target of anti-inflammatory drug development, in which...
Published: 7/25/2024   |   Inventor(s): Perry Blackshear
Keywords(s): Cells, DISEASES, Increasing, INFLAMMATORY, Listed LPM Reichman as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, THERAPY, TISSUES, Tristetraprolin, TTP, WIXXXX
Category(s): Collaboration Sought > Licensing, Application > Research Materials
Modified AAV5 Vectors for Enhanced Transduction and Reduced Antibody Neutralization
Scientists at the NIH disclosed a mutated adeno-associated virus (AAV) serotype 5 by modifying sialic acid binding regions which mediate viral entry into host cells. Preliminary results from animal studies suggest that this modification can increase transduction by 3-4 folds in salivary glands and muscles, and can significantly decrease the potential...
Published: 7/25/2024   |   Inventor(s): Sandra Afione-Wainer, Mavis Agbandje-Mckenna, Sujata Halder, John (Jay) Chiorini
Keywords(s): AAV5, ANTIBODY, ENGINEERED, Enhanced, GENETICALLY, Listed LPM Reichman as of 4/15/2015, Neutralization, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, REDUCED, transduction, VAXXXX, VCXXXX, vectors, VFXXXX, VGXXXX, WJXXXX, XEXXXX, YAXXXX, YCXXXX
Category(s): TherapeuticArea > Immunology, TherapeuticArea > Geriatrics, TherapeuticArea > Endocrinology, TherapeuticArea > Oncology, Application > Therapeutics
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