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Peptide Mimetic Ligands of Polo-like Kinase 1 Polo Box Domain (“Plk1 PBD Portfolio”)

Abstract: Polo-like kinase 1 (Plk1) is a critical protein involved in regulation of mitosis, and aberrant expression of this kinase is found in various cancer types. Inhibition of Plk1 is currently being pursued in pre-clinical drug development for novel anti-cancer therapeutics. Plk1 contains an allosteric domain, known as the polo-box domain (PBD),...

Published: 5/22/2024 | Inventor(s): Terrence Burke, Jung-Eun Park, Wen-Jian Qian, Fa Liu, Kyung Lee

Keywords(s): Burke, CANCER, mitosis, Peptide Inhibitor, polo-box domain (PBD), Polo-like kinase 1 (Plk1), therapeutic

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics

A New Mouse Monoclonal Antibody Against Human Microphthalmia Transcription Factor (MITF)

Micropthalmia Transcription Factor (MITF) plays an important role in melanocyte development and melanoma growth. MITF is important for embryonic development, regulating the generation of pigment cells and formation of melanomas and other tumors. MITF is made in various isoforms that may play unique roles for different organs during different developmental...

Published: 4/8/2024 | Inventor(s): Wen Fang Liu, Hideki Murakami, Heinz Arnheitter

Keywords(s): ANTIBODY, CANCER, CC2XXX, CCXXXX, CXXXXX, factor, Human, Microphthalmia, MITF, monoclonal, Mouse, RELATED, transcription

Category(s): Collaboration Sought > Licensing, Collaboration Sought > Materials Available, TherapeuticArea > Oncology, Application > Research Materials