Search Results - listed+lpm+nguyen-antczak+as+of+4%2f15%2f2015

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Creation and Use of 12-LO inhibitors (4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives) for the Treatment of Diabetes and Large Platelet-Derived Clots

This technology includes the discovery and use of novel selective 12-LO (lipoxygenase) inhibitors, 4-((2-hydroxy-3-methoxybenzyl)amino)benzenesulfonamide derivatives, for attenuating large clots and for the treatment of Type 1/2 diabetes. A 12-LO inhibitor could be a potent intracellular approach to block platelets from forming large clots in response...

Published: 7/25/2024 | Inventor(s): Ajit Jadhav, Anton Simeonov, Adam Yasgar, Diane Luci, Michael Holinstat, Theodore Holman, Jerry Nadler, David Taylor-Fishwick, David Maloney

Keywords(s): 12-Lipoxygenase., 4-2-hydroxy-3-methoxybenzylaminobenzenesulfon, Derivatives, Discovery, Human, Inhibitors, Listed LPM Nguyen-Antczak as of 4/15/2015, Post LPM Assignment Set 20150420, POTENT, Pre LPM working set 20150418, SELECTIVE, VDXXXX, VFXXXX, WKXXXX, XEXXXX

Category(s): TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Therapeutics

Process for Practical, Scalable, Commercially-viable Method for the Synthesis of Enantio-enriched Aminoalcohols, Including the Novel Antifungal VT-1129 Used to Treat Cryptococcal Meningitis

This technology relates to the discovery and development of a practical, scalable, and commercially viable method for the synthesis of the novel antifungal VT-1129. Cryptococcal meningitis (CM) is a fungal infection that is particularly prevalent in immune-compromised patients and can be treated by VT-1129. CM has a current estimated patient population...

Published: 7/25/2024 | Inventor(s): Mark Behnke, Scott David, Douglas Fry, William Hoekstra, Christopher Yates, Asaf Alimardanov

Keywords(s): Acid, Alcohol, Aminoalcohols, Benzenesulfonic, BSA., Co-crystal, Containing, Derivatives, Enantioenriched, Fragment, Including, Listed LPM Nguyen-Antczak as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PROCESS, Synthesis, Tertiary, THOSE, VEXXXX, VT-1129, WMXXXX

Category(s): Application > Consumer Products, TherapeuticArea > Neurology

Hybridoma Cell Line H9.2B8 Producing Monoclonal Anti-mouse CD51 (Vitronectin receptor, alpha chain) Antibody

A hybridoma cell line producing a monoclonal hamster antibody specific to mouse CD51 (vitronectin receptor, alpha chain) (clone H9.2B8) as described in J Exp Med. 1989 Jun 1;169(6):2173-90 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): AC5XXX, Against, ALPHA, antibodies, ANTIGENS, Cell, Chain, Clone:, H9.2B8, Hamster, Hybridoma, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, Mouse, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, RM, Surface, Vitronectin, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Hybridoma Cell Line H1.2F3 Producing Monoclonal Anti-mouse CD69 (Early activation marker) Antibody

A hybridoma cell line producing a monoclonal hamster antibody specific to mouse CD69 (early activation marker) (clone H1.2F3) as described in J Immunol. 1988 Jul 15;141(2):369-76 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): 141:369-376, 1988, AC5XXX, Cell, H12F3, Hybridoma, Immunology, J., Line, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Hybridoma Cell Line D7 Producing Monoclonal Anti-mouse Ly-6A/E (Sca-1) Antibody

A hybridoma cell line producing a monoclonal rat antibody specific to mouse Ly-6A/E (Sca-1) (clone D7) as described in J Immunol. 1986 Nov 15;137(10):3240-6 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): 137:3240-3246, 1986, AC5XXX, Cell, D7, Hybridoma, Immunology, J., Line, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Hybridoma Cell Line 3C7 Producing Monoclonal Anti-mouse CD25 (IL-2 receptor, alpha chain) Antibody

A hybridoma cell line producing a monoclonal rat antibody specific to mouse CD25 (IL-2 receptor, alpha chain) (clone 3C7) as described in J Immunol. 1984 Oct;133(4):1970-5 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): 133:1970, 1983, 3C7, AC5XXX, Cell, Hybridoma, Immunology, J., Line, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Hybridoma Cell Line 7D4 Producing Monoclonal Anti-mouse CD25 (IL-2 receptor) Antibody

A hybridoma cell line producing a monoclonal rat antibody specific to mouse CD25 (IL-2 receptor) (clone 7D4) as described in Proc Natl Acad Sci U S A. 1983 Sep;80(18):5694-8 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): 1983, 7D4, 80:5694-5698, AC5XXX, Cell, Hybridoma, Line, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, PNAS, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

ApoA-1 Mimetic Peptides Promoting Lipid Efflux from Cells for Treatment of Vascular Disorders

This invention involves ApoA-1 mimetic peptides with multiple amphipathic alpha-helical domains that promote lipid efflux from cells and are useful in the treatment and prevention of dyslipidemic, inflammatory and vascular disorders. IND-enabling studies for one of the peptides, named Fx-5A, are completed in preparation for an IND filing at the FDA,...

Published: 7/25/2024 | Inventor(s): Edward Neufeld, Fairwell Thomas, H. Bryan Brewer, Stephen Demosky, John Stonik, Marcelo Amar, Alan Remaley

Keywords(s): (4)r syndrome, 3-@hydroxyacyl-coa dehydrogenase deficiency, AMPHIPATHIC, assay, Atherosclerosis., C syndrome, Chromosome 4 ring syndrome, Chromosome 6 ring syndrome, Chromosome 7 ring syndrome, COMPOSITION, G syndrome, HAD deficiency, HELICAL, HIS deficiency, Histidinemia, Hyperlipoproteinemia, Hypertelorism with esophageal abnormality and hypospadias, IA1XXX, IAXXXX, IXXXXX, Listed LPM Nguyen-Antczak as of 4/15/2015, Multi-domain, N syndrome, Patent Category - Biotechnology, Peptides, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R(6) syndrome, R(7) syndrome, Syndrome X, System, treatment, UA1XXX, VDXXXX, VHXXXX, W syndrome, W syndrome; Syndrome W, WJXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Diagnostics

Method for the Diagnosis and Treatment of Vascular Disease

Cardiovascular disease is a major health risk throughout the industrialized world. Atherosclerosis, the most prevalent of cardiovascular diseases, is the principal cause of heart attack, stroke, and gangrene of the extremities. It is also the principal cause of death in the United States. This invention portrays a method for diagnosing decreased vascular...

Published: 7/25/2024 | Inventor(s): Arshed Quyyumi, Jonathan Hill, Toren Finkel

Keywords(s): Cells, Diagnosis, Disease, Endothelial, IAXXXX, IXXXXX, Listed LPM Nguyen-Antczak as of 4/15/2015, Method, Patent Category - Biotechnology, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Progenitor, treatment, vascular

Category(s): Collaboration Sought > Licensing, Application > Research Materials, Application > Diagnostics, Application > Therapeutics

Hybridoma Cell Line G7 Producing Monoclonal Anti-mouse CD90 (Thy-1) Antibody

A hybridoma cell line producing a monoclonal rat antibody specific to mouse CD90 (Thy-1) (clone G7) as described in J Exp Med. 1984 Mar 1;159(3):716-30 and developed by the laboratory of Dr. Ethan Shevach at the National Institute of Allergy and Infectious Diseases.

Published: 7/25/2024 | Inventor(s): Ethan Shevach

Keywords(s): 159:716, 1984, AC5XXX, Cell, Exp., G7, Hybridoma, J., Line, Listed LPM Nguyen-Antczak as of 4/15/2015, Mab, Med., Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RM, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials