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Novel Codon-Optimized MUT Gene Therapeutic for Methylmalonic Acidemia (MMA)
Methylmalonic Acidemia (MMA) is a metabolic disorder characterized by increased acidity in the blood and tissues due to toxic accumulation of protein and fat by-products resulting in seizures, strokes, and chronic kidney failure. A significant portion of MMA cases stem from a deficiency in a key mitochondrial enzyme, methylmalonyl-CoA mutase (MUT),...
Published: 7/25/2024
|
Inventor(s):
Colin Shea
,
Ciprian Crainiceanu
,
Elizabeth Sweeney
,
Russell Shinohara
,
Arthur Goldsmith
,
Daniel Reich
Keywords(s):
Automatic
,
brain
,
Detection
,
IMAGING
,
Incidence
,
Lesion
,
Listed LPM Shmilovich as of 4/15/2015
,
Longitudinal
,
Magnetic
,
MULTIMODALITY
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Resonance
,
software
,
SuBLIME:
,
VPXXXX
,
WJXXXX
,
XEXXXX
Category(s):
TherapeuticArea > Cardiology
,
TherapeuticArea > Oncology
,
TherapeuticArea > Ophthalmology
,
Application > Therapeutics
,
TherapeuticArea > Endocrinology
,
TherapeuticArea > Dental
,
TherapeuticArea > Infectious Disease
OASIS: Automated brain lesion detection using cross-sectional multimodal magnetic resonance imaging
This invention is a novel statistical method for automatically detecting lesions in cross-sectional brain magnetic resonance imaging (MRI) studies. OASIS uses multimodal MRI from one image acquisition session and produces voxel-level probability maps of the brain that quantifies the likelihood that each voxel is part of a lesion. Binary lesion segmentations...
Published: 7/25/2024
|
Inventor(s):
Ciprian Crainiceanu
,
Elizabeth Sweeney
,
Russell Shinohara
,
Arthur Goldsmith
,
Navid Shiee
,
Dzung Pham
,
Daniel Reich
Keywords(s):
Automated
,
brain
,
CNRM CRADA
,
Cross
,
Detection
,
IMAGING
,
Lesion
,
Listed LPM Shmilovich as of 4/15/2015
,
Magnetic
,
MULTIMODALITY
,
OASIS:
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Resonance
,
SECTIONAL
,
software
,
VEXXXX
,
WBXXXX
,
WIXXXX
,
XFXXXX
Category(s):
Collaboration Sought > Licensing
,
Application > Medical Devices
,
Application > Research Materials
,
Application > Software / Apps
,
Application > Diagnostics
,
Application > Non-Medical Devices
,
TherapeuticArea > Neurology
Adaptor for Suspending a Cryovial Over a Centrifuge Tube
The invention pertains to a device and system for expediting the thawing of frozen specimens (e.g., cryopreserved cells) contained in cryo-vials. An adaptor support suspends cryo-vials over a centrifuge tube containing culture medium in an inverted position. The adaptor has an elongated tubular body. While relatively basic, the adaptor dramatically...
Published: 4/8/2024
|
Inventor(s):
Margaret Beddall
,
Pratip Chattopadhyay
,
Mario Roederer
Keywords(s):
AC3XXX
,
AC4XXX
,
AC6XXX
,
ADAPTER
,
AFXXXX
,
Cells
,
Cryopreservation
,
Cryopreserved
,
Cryo-sample
,
FROZEN
,
Listed LPM Shmilovich as of 4/15/2015
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Thawing
,
WIXXXX
,
WMXXXX
,
XDXXXX
,
YFXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Consumer Products
,
Application > Non-Medical Devices
,
Application > Medical Devices
,
Application > Research Materials
Real Time Medical Image Processing Using Cloud Computing
The invention pertains to a system for reconstructing images acquired from MR and CT scanners in a robust Gadgetron based cloud computing system. A hardware interface connects clinical imaging instruments (e.g., MR or CT scanners) with a cloud computing environment that includes image data reconstruction and processing software not limited by the computational...
Published: 7/25/2024
|
Inventor(s):
Hui Xue
,
Peter Kellman
,
Michael Hansen
Keywords(s):
AD1XXX
,
AD2XXX
,
AD3XXX
,
Cloud
,
Computing
,
CT
,
DATA
,
Gadgetron
,
IMAGING
,
Listed LPM Shmilovich as of 4/15/2015
,
Magnetic Resonance
,
MEDICAL
,
MRI
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
Processing
,
Raw
,
REAL-TIME
,
XFXXXX
,
XJXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Software / Apps
,
ResearchProducts > Computational models/software
,
Application > Medical Devices
,
Application > Non-Medical Devices
,
Application > Diagnostics
Capillary Viscometer for Measuring Viscosity of Macromolecular Solutions of Biological Relevance
A capillary-based device and system for measuring the rheological properties of solutions of synthetic and biological polymers. The device automatically serially dilutes and varies the flow rate of a sample, permitting measurement of solution viscosity across wide ranges of concentration and shear rate without changing samples. The device can rapidly...
Published: 7/25/2024
|
Inventor(s):
Asaf Grupi
,
Allen Minton
Keywords(s):
AC3XXX
,
AC4XXX
,
ACXXXX
,
Automated
,
AXXXXX
,
Listed LPM Shmilovich as of 4/15/2015
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
rheology
,
Viscometer/rheometer
,
VISCOSITY
,
WIXXXX
,
XDXXXX
,
YBXXXX
,
YFXXXX
Category(s):
Collaboration Sought > Collaboration
,
Application > Research Materials
,
Application > Medical Devices
,
Application > Non-Medical Devices
Three-Dimensional Curved Catheter for Right Atrial Appendage Traversal
Available for licensing and commercial development is a three-dimensionally configured curved catheter for safe traversal of the right atrial appendage (RAA). The device is configured to optimize one-way access of the pericardial space through the right atrium and into the RAA reducing the risk of coronary lacerations. Specifically the curved catheter...
Published: 7/25/2024
|
Inventor(s):
Toby Rogers
,
Nasser Rafiee
,
Adam Greenbaum
,
William O'Neill
,
Robert Lederman
Keywords(s):
AB3CXX
,
AB3EXX
,
AB3FXX
,
AB3GXX
,
AB3XXX
,
Cardiovascular
,
catheter
,
Listed LPM Shmilovich as of 4/15/2015
,
Pericardial
,
Post LPM Assignment Set 20150420
,
Pre LPM working set 20150418
,
VDXXXX
,
WMXXXX
,
XDXXXX
,
YAXXXX
,
YFXXXX
Category(s):
Collaboration Sought > Collaboration
,
Collaboration Sought > Licensing
,
Application > Consumer Products
,
TherapeuticArea > Cardiology
,
Application > Non-Medical Devices
,
Application > Medical Devices
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