Search Results - therapeuticarea+%3e+nephrology

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New Insect Sf9-ET Cell Line for Determining Baculovirus Titers

Abstract: The baculovirus-based protein expression system has gained increased prominence as a method for expressing recombinant proteins that are used in a wide range of biomedical applications. An important step in the use of this system is the ability to determine the virus infectious titer, i.e., the number of active baculovirus particles produced...

Published: 5/22/2024 | Inventor(s): Ralph (Butch) Hopkins, Dominic Esposito

Keywords(s): Baculovirus, Baculovirus Titer, Esposito, IMMUNE, Inflammation, Insect Cell Line, Protein Expression Sf9-ET

Category(s): TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, Collaboration Sought > Licensing, TherapeuticArea > Reproductive Health, TherapeuticArea > Nephrology, Application > Research Materials, TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Dermatology, TherapeuticArea > Immunology, TherapeuticArea > Oncology

Improved Gene Therapy Vectors for the Treatment of Glycogen Storage Disease Type Ia (GSD-1a)

Abstract: GSD-Ia is an inherited disorder of metabolism associated with life-threatening hypoglycemia, hepatic malignancy, and renal failure caused by the deficiency of glucose-6-phosphatase-alpha (G6Pase-alpha or G6PC). Current therapy, which primarily consists of dietary modification, fails to prevent long-term complications in many patients, including...

Published: 4/8/2024 | Inventor(s): Janice Chou, Barry Byrne

Keywords(s): Chou, GSD-1a, hepatic malignancy, hyperlipidemia, hypoglycemia, National Institute of Child Health and Human Development, NICHD

Category(s): TherapeuticArea > Nephrology, Application > Therapeutics, Collaboration Sought > Licensing, Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology

Strategies to Protect Mammalian Neural Tissue Against Cold and Potentially Other Metabolic Stresses and Physical Damages

Abstract: Researchers at the National Eye Institute (NEI) have discovered an invention describing a composition and method(s) of using such composition for preserving viability of cells, tissues, or organs at a low temperature (around 4ºC). Current cold storage solutions or methods for cells, tissues, and organs are suboptimal due to irreversible...

Published: 4/8/2024 | Inventor(s): Jingxing Ou, Wei Li, Kiyoharu Miyagishima

Keywords(s): Cold Storage, Cold-sensitive, Hypothermia, lysosome, Mitochondria, National Eye Institute, NEI, neural injury, Ou, Protein Degradation, TRANSPLANTATION

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Research Materials, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Nephrology

A peptide hydrogel for use in vascular anastomosis

Abstract: In collaboration with surgery specialists from Johns Hopkins University, researchers at the National Cancer Institute (NCI) developed novel hydrogel compositions and methods of using them in the microsurgical suturing of blood vessels, which is particularly beneficial for surgeons in whole tissue transplant procedures. The lead candidate electropositive...

Published: 4/8/2024 | Inventor(s): Joel Schneider, Gerald Brandacher, Daniel Smith, Gabriel Brat, Johanna Grahammer

Keywords(s): Anastomosis, Hydrogel, Microsurgery, Peptide, Schneider, Surgery

Conformational Restriction of Cyanine Fluorophores in Far-Red and Near-IR Range

Abstract: Small molecule fluorescent probes are important tools in diagnostic medicine. Existing far-red and near-IR cyanine fluorophores (e.g. Cy5, Alexa 647, Cy7, ICG) are active in the far-red and near-range, but these agents suffer from modest quantum yields (brightness) which limit wide utility. It has been reported that the limited brightness...

Published: 4/8/2024 | Inventor(s): Martin Schnermann, Megan Michie

Keywords(s): CANCER, Cardiovascular, cyanine fluorophores, FACS, Fluorescence guided surgery, Fluorescent probes, gastrointestinal (GI), IMAGING, KIDNEY, Schnermann, super resolution microscopy

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Oncology, Collaboration Sought > Licensing, TherapeuticArea > Cardiology, Application > Diagnostics, TherapeuticArea > Gastroenterology, TherapeuticArea > Nephrology

Gene Therapy Vector for the Treatment of Glycogen Storage Disease Type Ia (GSD-Ia)

Published: 4/8/2024 | Inventor(s): Janice Chou

Keywords(s): GSD-Ia, hepatic malignancy, hypoglycemia, renal failure

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Nephrology, Collaboration Sought > Collaboration, Application > Therapeutics

Bac-2-the-Future: An Improved System for Production of Recombinant Baculovirus

Abstract: Baculoviruses have been used for decades to produce proteins in insect cell hosts. Current systems for generating recombinant baculovirus have several shortcomings which prevent their easy use in high-throughput applications. Researchers within the Frederick National Laboratory for Cancer Research have developed an improved system called...

Published: 5/22/2024 | Inventor(s): Dominic Esposito, Carissa Grose

Keywords(s): B2F, Bac-2-the-Future, Baculovirus, Esposito, Insect Cells, Protein Production

Category(s): TherapeuticArea > Gastroenterology, TherapeuticArea > Endocrinology, TherapeuticArea > Infectious Disease, TherapeuticArea > Cardiology, TherapeuticArea > Opthamology, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Reproductive Health, TherapeuticArea > Immunology, TherapeuticArea > Dermatology, Collaboration Sought > Licensing, Application > Research Materials, TherapeuticArea > Oncology, TherapeuticArea > Nephrology