Search Results - listed+lpm+contreras+as+of+4%2f15%2f2015

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Lymphoblastoid Cell Lines with a Specific Allele of ABCA7 Gene for the Screening of Small Molecules for Therapeutic Development

This technology includes lymphoblastoid cell lines from individuals genotyped as carrying the minor (G) allele of ABCA7 SNP rs113809142 [ss491752998; SNV-chr19-1007244], to be used for small molecule screening and eventual therapeutic development. The ABCA7 gene is the ATP-binding cassette, sub-family A (ABC1), member 7. It encodes a protein that is...

Published: 7/25/2024 | Inventor(s): James ("Jim") Mullikin, Jennifer Johnston, Leslie Biesecker

Keywords(s): ABCA7, ALLELE, Cell, Gene, Lines, Listed LPM Contreras as of 4/15/2015, Lymphoblastoid, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, Specific, VHXXXX, VPXXXX, WIXXXX, WJXXXX, XEXXXX

Category(s): TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Dental, TherapeuticArea > Oncology, TherapeuticArea > Ophthalmology, Application > Research Materials, TherapeuticArea > Cardiology, TherapeuticArea > Infectious Disease

Development of a Polyclonal Antibody for Neuroligin 4 pThr707 and a Polyclonal Antibody for Neuroligin 1 pTHR739

This invention includes the generation and use of two polyclonal antibodies that specifically recognizes the phosphorylation site pThr707 of Neuroligin 4 and pThr739 of Neuroligin 1. A peptide of the site around the phosphorylation site was generated and injected into rabbits to create an immune response. Serum was collected from the rabbits that was...

Published: 7/25/2024 | Inventor(s): Michael Bemben, John Badger, Katherine Roche

Keywords(s): 1, 4, ANTIBODY, Development, Listed LPM Contreras as of 4/15/2015, Neuroligin, polyclonal, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PThr707, THR739, VEXXXX, WBXXXX, WIXXXX, XAXXXX

Category(s): TherapeuticArea > Neurology, TherapeuticArea > Immunology, Application > Diagnostics, ResearchProducts > Antibodies, Application > Research Materials

Genome Wide DNase I Hypersensitive Sites Detection in Formalin-Fixed Paraffin-Embedded Single Cells

A method of detecting DNase I hypersensitive sites ((DHS) in a single cell or very small number of cells, including cells recovered from formalin-fixed paraffin-embedded (FFPE) tissue slides of patient samples. DHS has revealed a large number of potential regulatory elements for transcriptional regulation in various cell types. The application of...

Published: 4/8/2024 | Inventor(s): Qingsong Tang, Keji Zhao

Keywords(s): amplification, AMPLIFICATION-BASED, assay, CHROMATIN, DNase-Seq, Listed LPM Contreras as of 4/15/2015, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Single-cell, TECHNIQUE, VCXXXX, WBXXXX, WIXXXX, XGXXXX, XHXXXX, YAXXXX, YBXXXX

Category(s): Collaboration Sought > Licensing, Application > Consumer Products, Application > Therapeutics, TherapeuticArea > Oncology, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Research Materials

Diagnostic Test and Therapeutic Target for Sjogren's Syndrome

Sjögren's syndrome is an autoimmune disease that attacks salivary glands resulting in chronic dry mouth and dry eyes. Currently, there is no single diagnostic test to confirm the presence of Sjögren's. Physicians presently reach diagnosis after conducting a series of blood and functional tests for tear and salivary production. Diagnosis is further...

Published: 7/25/2024 | Inventor(s): Melodie Weller, Hongen Yin, John (Jay) Chiorini

Keywords(s): Alteration, BMP6, Detection, Diagnosis, Expression, Gland, IA3XXX, IAXXXX, IXXXXX, LEVELS, Listed LPM Contreras as of 4/15/2015, Locally, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Salivary, Sjogren's, Syndrome, treatment

Category(s): TherapeuticArea > Immunology, Application > Diagnostics, Application > Research Materials, Application > Therapeutics

Adeno-Associated Virus Gene Therapy for Diabetes and Obesity

This invention is directed to adeno-associated virus (AAV) vector delivery of exendin-4 (Ex-4) to salivary glands as treatment for diabetes and obesity. Ex-4 is a potent and long-acting agonist of the receptor for glucagon-like peptide 1 (GLP-1). Scientists at NIDCR have shown that AAV-mediated delivery of Ex-4 resulted in improved glucose homeostasis...

Published: 7/25/2024 | Inventor(s): Giovanni Di Pasquale, Edward Mannucci, John (Jay) Chiorini

Keywords(s): DIABETES, EPITHELIA, Expression, Fusion, GBXXXX, Gland, IBXXXX, Listed LPM Contreras as of 4/15/2015, NGF/exendin-4, Novel, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Protein, Salivary, treatment

Category(s): Application > Therapeutics

Gene Therapy for Niemann-Pick Disease Type C

Investigators at the National Human Genome Research Institute (NHGRI) of the National Institutes of Health (NIH) are seeking collaborators to further develop gene therapy to treat Niemann-Pick Disease Type C (NPC). NPC is a rare, autosomal recessive, neurodegenerative disease. Approximately 95% of patients with NPC have mutations in NPC1, a gene implicated...

Published: 7/25/2024 | Inventor(s): Randy Chandler, William ("Bill") Pavan, Charles Venditti

Keywords(s): Adeno-associated, C, Disease, Gene, Listed LPM Contreras as of 4/15/2015, NIEMANN-PICK, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, THERAPY, treatment, TYPE, VEXXXX, VHXXXX, viral, WJXXXX, XEXXXX

Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Endocrinology, Application > Therapeutics, TherapeuticArea > Neurology

Mouse Strain CAR-KO C3H/HeNCrl, Deletion of Nuclear Xenobiotic Receptor CAR

CAR (nuclear constitutive active receptor) is a member of the nuclear receptor superfamily, and is a key regulator of xenobiotic and endobiotic metabolism. It is primarily responsible for sensing foreign toxic substances and in response up regulating the expression of proteins involved in the detoxification and clearance of these substances from the...

Published: 7/25/2024 | Inventor(s): Masahiko Negishi

Keywords(s): ACXXXX, C3H/HeNCrl, CAR, CAR-KO, Deletion, Listed LPM Contreras as of 4/15/2015, Mouse, nuclear, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RECEPTOR, Strain, WIXXXX, Xenobiotic

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Leucine Rich Repeats and Calponin Homology Containing Protein 4 (Lrch4)-deficient Mouse

Leucine rich repeats and calponin homology containing protein 4 (Lrch4) is a gene that encodes a protein predicted to have a C-terminal transmembrane domain, a calponin homology domain, and 5-8 leucine rich repeats (LRRs). We silenced Lrch4 in RAW 264.7 macrophages as well as CD14-MD2-TLR4-HEK293 cells and found that Lrch4 knockdown attenuates responsiveness...

Published: 7/25/2024 | Inventor(s): Jim Aloor, Michael Fessler

Keywords(s): Generation, Listed LPM Contreras as of 4/15/2015, Lrch4-deficient, Murine, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, RXXXXX, Strain, WIXXXX

Category(s): Collaboration Sought > Licensing, Application > Research Materials

Development of Reagents to Examine the Expression and Function of CYP2J Subfamily P450s

Cytochrome P450s catalyze the metabolism of a wide range of exogenous compounds, including drugs, industrial chemicals, environmental pollutants, and carcinogens. The 2C family of cytochrome P450 metabolizes an extensive number of drugs which include tolbutamide, S-Warfarin, mephenytoin, diazepam and taxol. The inventors cloned the cDNAs for several...

Published: 7/25/2024 | Inventor(s): Darryl Zeldin, Jennifer Bradbury

Keywords(s): CYP2J, Development, Examine, Expression, FUNCTION, Listed LPM Contreras as of 4/15/2015, P450s, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, R1XXXX, REAGENTS, RXXXXX, SUBFAMILY

Category(s): Collaboration Sought > Collaboration, Application > Research Materials