Search Results - therapeuticarea+%3e+rare+%2f+neglected+diseases

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TYROSINASE Gene Therapy for Oculocutaneous Albinism type 1A

Summary: The National Eye Institute seeks research co-development partners and/or licensees for an adeno-associated viral gene therapy for Oculocutaneous Albinism type 1A. Description of Technology: Oculocutaneous albinism (OCA) is a genetically heterogeneous congenital disorder characterized by decreased or absent pigmentation in the hair,...

Published: 8/14/2024 | Inventor(s): Brian Brooks, Aman George

Keywords(s):

Category(s): Application, Application > Therapeutics, Collaboration Sought > Collaboration, TherapeuticArea > Eye / Ear / Nose / Throat, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Ophthalmology

Alpha-galactosidase-A Knockout Mouse Model for Studying Fabry Disease

This technology includes an alpha-galactosidase-A knockout mouse model that can be used to study Fabry disease, an X-linked lysosomal storage disorder. Alpha-galactosidase-A is a crucial enzyme responsible for the breakdown of glycolipids, particularly globotriaosylceramide (Gb3), within lysosomes. In Fabry disease, a rare and inherited lysosomal storage...

Published: 4/8/2024 | Inventor(s): Toshio Ohshima, Ashok Kulkarni, Roscoe Brady, Gary Murray

Keywords(s):

Category(s): Application > Research Materials, Application > Therapeutics, Application > Vaccines, Collaboration Sought > Materials Available, ResearchProducts > Animal Models, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Metabolic Disease

Polypeptides and Methods for Enhancing and Balancing Monovalent or Multivalent Flavivirus Vaccines

CDC researchers have developed a potent immunogenic enhancer polypeptide useful for improving flavivirus vaccines. Flaviviruses such as dengue virus (1, 2, 3 and 4), Japanese encephalitis virus, Murray Valley encephalitis virus, St. Louis encephalitis virus, yellow fever virus and tick-borne encephalitis virus are a great burden on public health. ...

Published: 7/25/2024 | Inventor(s): Holly Hughes, Gwong-Jen Chang

Keywords(s): ADJUSTMENT, adjuvant, Adjuvant-like, BCXXXX, Boost, BOOSTING, CD4, CDC Docket Import, CDC Docket Import CDC Prosecuting, Cell, DB4BXX, DB4XXX, DC1XXX, DC5BXX, DC5XXX, DCXXXX, DDXXXX, DENGUE, DENGUE FEVER, Dengue Vaccine, Dengue-1, Dengue-2, Dengue-Like, DXXXXX, Epitope, Flavivirus, FLAVIVIRUSES, Identification, in vivo, JAPANESE ENCEPHALITIS VIRUS, Listed LPM Houze as of 4/15/2015, Mosquito, Mosquitoes, Nile, OID-NCEZID-DVBD, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PRIMER, T, THEREOF, Tick-Bone, TICK-BORNE, UBXXXX, Vaccine, Vaccine Design, VACCINE DEVELOPMENT, VBXXXX, Vector-borne, Vector-borne diseases, virus, VLXXXX, VOXXXX, WAXXXX, West, WIXXXX, WJXXXX, WMXXXX, XCXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines, Application > Therapeutics, Application > Research Materials, Application > Consumer Products, TherapeuticArea > Infectious Disease

Entangling/Entrapping Synthetic Setae for Control of Insects and Other Pests

In nature, some beetle larvae possess specialized barbed hastate setae that serve as an entanglement defense mechanism and incapacitate other insects. CDC researchers have developed synthetic setae for control and entrapment of insects and other pests. While smaller synthetic setae can trap mosquitoes and small insects, larger “macro” setae can be...

Published: 7/25/2024 | Inventor(s): Robert Wirtz

Keywords(s): AE2BXX, AE2XXX, AEXXXX, AFXXXX, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, CONTROL, DB2XXX, DB4XXX, DBXXXX, DEVICE, Devices, DEXXXX, DXXXXX, Entangling, Entrapment, insect, Insects, Mosquito, Mosquitoes, Net, Pest, Pests, population sampling, PXXXXX, Setae, TRAP, UBXXXX, UXXXXX, Vector-borne, Vector-borne diseases, VJXXXX, VKXXXX, VLXXXX, VOXXXX, WCXXXX, WDXXXX, WFXXXX, WIXXXX, WMXXXX, XDXXXX, XIXXXX, YFXXXX, Zoo

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, Application > Medical Devices, TherapeuticArea > Rare / Neglected Diseases, Application > Research Materials, Application > Occupational Safety and Health, Application > Non-Medical Devices, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Infectious Disease

T24 Antigen for Diagnosing or Treating Taenia solium Cysticercosis

In order to develop a simple detection assay for field use, CDC researchers cloned and sequenced the Taenia solium T24 diagnostic protein. The T24 sequences can be used to detect and diagnose T. solium infection or can be formulated into a pharmaceutical composition. T. solium is a species of tapeworm. Intestinal infection with T. solium is referred...

Published: 7/25/2024 | Inventor(s): Fatima Williams, Melinda Yushak, Sowmya Pattabhi, Victor Tsang, Kathy Hancock

Keywords(s): AFXXXX, ANTIGEN, CDC Docket Import, CDC Docket Import CDC Prosecuting, CGH-DPDM, Cysticercosis, DA2XXX, DAXXXX, DB2XXX, DBXXXX, DC2XXX, DCXXXX, Immunodiagnosis, SOLIUM, T24, TAENIA, UBXXXX, UXXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Therapeutics, Application > Vaccines, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics

Nucleic Acid Amplification Technique for Rapid Diagnostic Analysis

CDC researchers developed a simple target-specific isothermal nucleic acid amplification technique, termed Genome Exponential Amplification Reaction (GEAR). The method employs a set of four primers (two inner and two outer). The outer primer pair targets three specific nucleic acid sequences at a constant 60°C, while the inner pair of primers accelerates...

Published: 7/25/2024 | Inventor(s): Prithiviraj Jothikumar, Vincent Hill, Jothikumar Narayanan

Keywords(s): AA2XXX, AA5XXX, AAXXXX, AC4XXX, AC5XXX, Acids, ACXXXX, amplification, AMPLIFYING, AXXXXX, DA1XXX, DA2XXX, DA3XXX, DA4XXX, DA5XXX, DAXXXX, DXXXXX, Exponential, Gear, Genome, Isothermal, Methods, Nucleic, REACTION, REAGENTS, UBXXXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease, Application > Diagnostics

Multiplex Assay for Detection of Dengue Virus

Dengue virus (DENV) is the cause of dengue illness (dengue fever, dengue hemorrhagic fever, and dengue shock syndrome). CDC researchers have developed a RT-PCR multiplex assay that, prior to sero-conversion, selectively detects dengue virus in biological or other fluid media, such as whole blood, plasma, or serum. The primers and probes from this assay...

Published: 7/25/2024 | Inventor(s): Edgardo Vergne, Gilberto Santiago, Jorge Munoz-Jordan

Keywords(s): Broad, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, DXXXXX, Serotypes, UB1XXX, virus

Category(s): Collaboration Sought > Licensing, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, TherapeuticArea > Infectious Disease

CDC Mosquito Trap for Control and Surveillance of Mosquitoes Including Carriers of Zika & Other Viruses

Mosquitoes are responsible for spreading many viruses that can make people sick, including dengue, Zika, chikungunya, yellow fever, and more. The Centers for Disease Control and Prevention's (CDC's) new autocidal gravid ovitrap (AGO) mosquito trap is an inexpensive, simple-to-assemble, and easy-to-maintain trap that targets female mosquitoes looking...

Published: 7/25/2024 | Inventor(s): Manuel Amador, Andrew Mackay

Keywords(s): Aedes, Aegypti, AFXXXX, AUTOCIDAL, AXXXXX, CDC Docket Import, CDC Docket Import CDC Prosecuting, CONTROL, DENGUE, DENGUE FEVER, DEXXXX, DXXXXX, GRAVID, insect, Insecticides, Insects, Listed LPM Houze as of 4/15/2015, Malaria, MALARIAL, Mosquito, Mosquitoes, MXXXXX, NON-TOXIC, OID-NCEZID-DVBD, OVITRAP, Pest, PESTICIDE, PESTICIDES, Pests, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, Surveillance, Targeting, Tool, TRAP, TRAPPING, UB1XXX, Vector, Vector-based, Vector-borne, Vector-borne diseases, VLXXXX, VOXXXX, VQXXXX, WDXXXX, WEST NILE, WEST NILE VIRUS, WFXXXX, XDXXXX, YFXXXX, Zika, Zoonotic

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, Application > Consumer Products, Application > Medical Devices, Application > Non-Medical Devices, Application > Research Materials, Application > Diagnostics, TherapeuticArea > Rare / Neglected Diseases, Application > Occupational Safety and Health, Application > Therapeutics

Use of Vitronectin as a Biomarker for the Detection of Dengue Hemorrhagic Fever

Dengue hemorrhagic fever (DHF) is a severe, potentially deadly infection spread by mosquitos. CDC scientists have identified vitronectin as an important biomarker of DHF. They have shown vitronectin is significantly reduced in DHF and severe dengue infections when compared to dengue non-hemorrhagic fever patients. Presently, DHF is established by assessing...

Published: 7/25/2024 | Inventor(s): Momar Ndao, Kay Tomashek, Betty Poole-Smith, Elizabeth Hunsperger

Keywords(s): assay, Biomarker, DA4BXX, DA4XXX, DAXXXX, DENGUE, Detection, diagnostic, DIFFERENTIATION, DXXXXX, FEVER, HEMORRHAGIC, HOST, UB1XXX

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Rare / Neglected Diseases, Application > Diagnostics, TherapeuticArea > Infectious Disease

Safer Attenuated Virus Vaccines with Missing or Diminished Latency of Infection

This technology describes recombinant viruses that have weakened ability to establish and/or maintain latency and their use as live vaccines. The viruses have one or more genetic mutations that allow for continued replication but that inhibit latency. The vaccine materials and methods for their construction are exemplified with the virus that causes...

Published: 7/25/2024 | Inventor(s): Lesley Pesnicak, Edward Cox, Jeffrey Cohen

Keywords(s): BUT, chickenpox, DC5BXX, DC5XXX, DCXXXX, DXXXXX, Impaired, Latency, MUTANT, Patent Category - Biotechnology, REPLICATION, UAXXXX, Vaccine, VARICELLA-ZOSTER

Category(s): Collaboration Sought > Licensing, TherapeuticArea > Infectious Disease, TherapeuticArea > Rare / Neglected Diseases, Application > Vaccines

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