Search Results - xiaoyuan+(shawn)+chen

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PET Imaging of lntegrin Expression with Suitably Labeled RGD Peptides for Multiple Diagnostic Purposes

This technology includes a number of dimeric RGD peptides which been developed and labeled with various PET isotopes (1BF, 68Ga, and 64Cu) for imaging integrin expression in cancer, inflammation, rheumatoid arthritis, myocardial infarct, stroke and traumatic injury. A number of these peptides have been translated into clinic for diagnosis and therapy...

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Lixin Lang, Gang NIU

Keywords(s):

Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Cardiology, TherapeuticArea > Immunology, TherapeuticArea > Neurology

Radiotherapy and Imaging Agent-based on Peptide Conjugated to Novel Evans Blue Derivatives with Long Half-life and High Accumulation in Target Tissue

This technology includes a newly designed, truncated Evans Blue (EB) form which allows labeling with metal isotopes for nuclear imaging and radiotherapy. Unlike previous designs, this new form of truncated EB confers site specific mono-labeling of desired molecules. The newly designed truncated EB form can be conjugated to various molecules including...

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss

Keywords(s):

Category(s): ResearchProducts > Research Equipment, TherapeuticArea > Oncology, Application > Diagnostics, Application > Research Materials

Evans Blue Modified Small Molecule-based Prostate-specific Membrane Antigen (PSMA) Radiotherapy and Nuclear Imaging

This technology includes anti-PSMA antibody labeled with 177Lu, which has shown to be an effective treatment for prostate cancer. Several small molecules targeting PSMA were also evaluated in prostate cancer patients labeled with betta emitters such as 177Lu. The most common one is 177Lu-PSMA-617 which is under clinical evaluation in many countries....

Published: 8/12/2024 | Inventor(s): Xiaoyuan (Shawn) Chen, Orit Jacobson weiss

Keywords(s):

Category(s): Application > Therapeutics, Collaboration Sought > Licensing, ResearchProducts > Antibodies, TherapeuticArea > Oncology

Evans Blue Dye Derivatives for Serum Albumin Labeling

The invention is an imaging agent and method of use for imaging blood pools and the lymphatic system. The imaging agent binds with high affinity to serum albumin, the most abundant serum protein, and can be tagged with several isotopes making it suitable for magnetic resonance imaging or positron emission tomographic imaging. To date, only very few...

Published: 7/25/2024 | Inventor(s): Lixin Lang, Gang NIU, Xiaoyuan (Shawn) Chen

Keywords(s): Albumin, BLUE, CA2BXX, Evans Blue, fluorene-18, IA4AXX, LABELED, LABELING, Listed LPM Fenn as of 4/15/2015, Magnetic Resonance, PET, Pet imaging, positron emission, Positron-Emitting, Post LPM Assignment Set 20150420, Pre LPM working set 20150418, PXXXXX

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics, TherapeuticArea > Oncology, Application > Consumer Products, Application > Diagnostics, Application > Research Materials

Boron Amino Acid Mimetics for PET Imaging of Cancer

Available for licensing and commercial development as imaging agents for positron emission tomography of cancer are boramino acid compounds. The inventors showed that mimetics created by substituting the carboxylate group (-COO-) of an amino acid with trifluoroborate (-BF3-) are metabolically stable and allow for the use of fluorene-18 (18F) as the...

Published: 7/25/2024 | Inventor(s): Zhibo Liu, Xiaoyuan (Shawn) Chen

Keywords(s): AA3CXX, Boramino, CA1CXX, CA2BXX, CA2CXX, Cancer diagnosis, Cancer diagnostic, fluorene-18, Mimetic, MIMETICS, positron emission, VCXXXX, WBXXXX, WIXXXX, XFXXXX, YAXXXX, YBXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Research Materials, Application > Medical Devices, Application > Diagnostics, Application > Non-Medical Devices, Application > Software / Apps, TherapeuticArea > Oncology

Octopod (8-Pointed Star) Iron Oxide Nanoparticles Enhance MRI T2 Contrast

The octopod-shaped iron oxide nanoparticles of this technology significantly enhance contrast in MRI imaging compared to spherical superparamagnetic iron oxide nanoparticle T2 contrast agents. These octopod iron oxide nanoparticles show a transverse relaxivity that is over five times greater than comparable spherical agents. Because the unique octopod...

Published: 7/25/2024 | Inventor(s): Jinhao Gao, Zhenghuan Zhao, Xiaoyuan (Shawn) Chen

Keywords(s): Agents, CA2CXX, Contrast, High-Performance, IMAGING, IRON, Magnetic, Nanoparticles, Non-spherical, OXIDE, PXXXXX, Resonance, T2, VCXXXX, VDXXXX, WBXXXX, XFXXXX, XGXXXX, YCXXXX

Category(s): Collaboration Sought > Collaboration, Application > Diagnostics, Application > Research Materials, TherapeuticArea > Cardiology, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology, Application > Software / Apps, Application > Non-Medical Devices, Application > Medical Devices

Ultra-sensitive Diagnostic Detects fg/mL-pg/mL Pathogen/Disease Protein by Visual Color Change

This technology is an ultra-sensitive colorimetric assay, based on an enzyme-catalyzed gold nanoparticle growth process, for detection of disease-associated proteins (biomarkers) and disease diagnosis. Current detection methods, such as ELISA immunoassays, measure concentrations above 0.1 ng/mL in a sample. PCR, although more sensitive than ELISA, requires...

Published: 7/25/2024 | Inventor(s): Dingbin Liu, Xiaoyuan (Shawn) Chen

Keywords(s): assay, AuNPbased, AuNP-based, Biomarkers, CA1XXX, COLORIMETRIC, DAXXXX, Detection, GOLD, Nanoparticle, Ultrasensitive, VCXXXX, VJXXXX, VLXXXX, WBXXXX, XCXXXX, XDXXXX, XHXXXX, YAXXXX, YBXXXX, YFXXXX

Category(s): Collaboration Sought > Collaboration, Application > Medical Devices, ResearchProducts > Research Equipment, Application > Diagnostics, Application > Non-Medical Devices, Application > Research Materials, TherapeuticArea > Infectious Disease, TherapeuticArea > Oncology

Dipicolylamine-based Nanoparticles for Delivery of Ligands

Many potential nucleic acid therapeutics have not transitioned from the research laboratory to clinical application in large part because delivery technologies for these therapies are not effective. Most nucleic acid delivery technologies are lipid-based or positively charged and require chemical or physical conjugation with the nucleic acid. These...

Published: 7/25/2024 | Inventor(s): Seulki Lee, Ki Young Choi, Xiaoyuan (Shawn) Chen

Keywords(s): Acid, DELIVERING, Derivatives, Dipicolylamine, GDXXXX, GXXXXX, Nucleic, THEREOF

Category(s): Collaboration Sought > Collaboration, Application > Therapeutics

Fast Acting Molecular Probes for Real-Time In Vivo Study of Disease and Therapeutics

This technology is for fast acting molecular probes made from a fluorescent quencher molecule, a fluorophore, an enzyme cleavable oligopeptide (for example targeted by protease) and FDA-approved polyethylene glycol (PEG) as well as associated methods to identify cell activity with these probes. Proteases regulate many cell processes such as inflammation...

Published: 7/25/2024 | Inventor(s): Seulki Lee, Lei Zhu, Xiaoyuan (Shawn) Chen

Keywords(s): AA3AXX, AA3XXX, AAXXXX, ACTING, Activity, AXXXXX, Beacon, fast, IMAGING, Molecular, PROTEASE, THEREOF, USES

Category(s): Collaboration Sought > Collaboration

Metallic Nanoparticles for Photothermal Therapy

The invention relates to the preparation and application of 20-150nm metallic nanoparticulate vesicles for photothermal anti-cancer therapy. The vesicles comprise metallic nanoparticles covalently bound to a hydrophilic and hydrophobic polymer. The preparation method generally entails dispersing a polymer-bound metallic nanoparticle in an organic...

Published: 7/25/2024 | Inventor(s): Jibin Song, Xiaoyuan (Shawn) Chen

Keywords(s): CB7XXX, Nanoparticle, Nanoparticle-Based, Nanoparticles, Nanoparticulate, phototherapy, Photothermal, Photothermal/Photodynamic, PXXXXX, XGXXXX, YBXXXX

Category(s): Collaboration Sought > Collaboration, Application > Research Materials, Application > Diagnostics, Application > Therapeutics, Application > Consumer Products, TherapeuticArea > Oncology

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